Not too difficult a choice for me! Clearly the Best Spyderco of 2016 for me is the Nirvana.
Other notable favorites for me are the 40th Anniversary Native 5, Pattada (an excellent knife!), Magnitude (the best Carey collab by a long shot!), and the Advocate. As RamZar pointed out, the GB2 and Mantra were Dec 2015 releases but they top my list too!
Huge shout out too to Spyderco for really pumping up production in their expanded Golden facility! The CQI changes on the Military are great (except I think they should not have updated the fluted Ti version), and they certainly came through on the steels we wanted on the PM2 platform (with clearly Cruwear taking the cake!). Here's to a great 2017 folks! Cheers, Radioactive