For an EVA knife you'd want something with a serrated edge to cut through the beta cloth used pretty much everywhere exposed to space (a fireproof glass fiber cloth that can resist the UV and atomic oxygen present at orbital altitudes).
A blunt tip for a rescue/survival tool, or a pointed tip if you expect to get into 'glove-to-glove' combat in space.
One thing few people think about is that the suits (including the gloves) are pressurized. This means that to close your hand in a pressurized space suit glove you are fighting pressure until you relax your hand (allowing the glove to resume it's molded shape). For this reason, most EVA tools have very large diameter handles with aggressive ribs that don't require the hand to close much for a secure grip.
Materials are interesting too. Lots of anodized aluminum (gold color anodize for man-rated structure, clear for equipment rated), some stainless (though it's bad thermally), and beryllium copper for working around pure oxygen or other flammable materials (non-sparking).
For Intravehicular Activity (IVA), pretty much any knife that would be useful on the ground would be good up there, but I'd want a brightly colored handle to spot the opened knife floating my way (because I got busy and forgot to close it)...
-rwponline