That's an interesting question and one I hadn't really considered until now. If the base of the handle was titanium or titanium alloy and maybe use something really grippy on the surface to give the handle significantly more purchase that might be awesome the more I think about it.
I'm going to have to do some deep thinking on that. Because the possibilities could really be rewarding if done right.
I've loved Titanium handles ever since I got my Titanium Spyderco ATR model many years back. The feel of that handle really intrigued me a lot. I would not be opposed to using another type of material on the surface for more grip.