Several folk have posted that a large folder (which seems to mean bigger than 4" blade herein) represents too much mechanical compromise for little or no benefit over a fixed blade.
In the main, I'd agree; I carry a fixed blade when practical/legal and I need the size and strength. However, the oversize folder has now become my EDC when I'm walking the footpaths of my area, particularly in spring and summer.
The foliage grows over the styles and narrow paths so quickly that they can become impassable. In these circumstances, a folding "hacker" is ideal (in my case, Rajah) as a large folder invariably has a long handle which keeps knuckles clear of brambles and hawthorn, while providing reach and speed. A cleared path can easily be maintained with an quickly deployed, OHO giant folder.
A freshly cleared style:
A fixed blade of equivalent reach and length would be less discreet (the Rajah goes in a pocket) and probably require 2 hands to stow. Keep in mind that I'm not carrying a pack on these walks and in summer only light clothes. A lot of useful knife can be hidden in a large folder.
As for hard use, I've used mine for clearing paths, hedge-laying and coppicing for about 6 months. So far it remains solid.
As far as I know, the only mainstream company making such comic folders is CS. I'd love to see Spyderco do a bravado-free super-size folder.