Possible? Yes, for sure, linerless G10 models have a long history in Spyderco.
On the other hand, why bother? I doubt you are going to save weight comparing to FRN+liners, or pure linerless FRN like on Pacific Salt 2. And if you want G10, you can go full liners, something like Knifecenter pakkawood exclusive, that had full liners.
In the pocket: Chaparral FRN, Native Chief, Police 4 K390, Pacific Salt SE, Manix 2 G10 REX45
On belt: Waterway