For a small fixed-blade, I really love how the Enuff feels in hand. There's a reasonable amount of swell & contouring to the handle, but it's still neutral enough that I can comfortably use it in a wide variety of grips.
I haven't handled a lot of big Spyderco fixed blades so my favourite in this category would probably be the Schempp Rock by default, since it's the only big Spyderco fixed-blade with which I have extensive use experience.
In terms of folders, my favourite handles are the ones in
the Introvert, UKPK/Caly 3, and Q Ball tied for 1st (they're very different knives but they feel like they were custom fitted to my hand), followed by the Native 5 & Yojimbo 2 for 2nd place. I don't know what my 3rd place choice is... probably a toss-up between the Li'l Temperance 3 & the Polestar.
Urban, I don’t know why it feels better than the UKPK, but it does.
Gayle Bradley 1, how to get the cutting edge right up to the fore finger.
And the big surprise for me has been the Pacific Salt, it even balances on the front finger.