My personal Top 5 Spydercos (I only include models I have actually handled myself, not ones I just think I´d like):
Stretch 1 FRN (ideally in HAP 40, but the VG 10 model is not far behind for me): Most versatile bladeshape I´ve ever experienced in any knife when it comes to daily EDC use. Very good ergos; edge exactly as long as I want it in normal use (so not TOO long, but long enough for food prep on the road)
Endura 4 FFG (again, favorite HAP 40, but VG 10 is really not a bad steel too): Though many with larger hands don´t like the finger grooves, for me (L to XL hands) they are just right somehow. Again, perfect edge-length; hand very close to the edge in a regular grip; slim carry
Chaparral FRN: Perfect for days when you actually DON`T want to carry a knife in the pocket; Very slim, still feeling solid, great slicer; perfect for IWB in shorts when running or unclipped in zippered pockets; great backlock (as good as the Native lock imho); design ingenious both in function and looks. small enough that a choil really makes sense for bigger hands to get a full four finger grip.
Shaman: Still do not own one, handled (and once carried a borrowd one) one several times. For me the best ergos of any Spyderco I ever held in hands (even better then the Manix) both in regular and choked up grip, probably especially for bigger hands. Cuts great despite the thick blade; Though heavy and large, it carries amazingly well. The kind of knife I do not NEED by all it´s specs but still really, really want to have and use.
PM 2: Zatx recently gifted one to me (see my post in "kindness of your hearts"), I like it way more than I expected; The ergos are more similar to the Stretch one than I figured, the handle seems to be made right for my hand. So much, that I wonder how people with larger hands than mine can like that knife; for me it fits like a glove, just 1 mm smaller and the handle would be too short probably;
PM 2 also made me like the comp lock, though I still prefer a good backlock.
Top three going by pocket-time: Endura 4 in VG 10/Micarta-scales; Stretch 1 in VG 10; Endura 4 in HAP 40