I really like the ergos of the Lil' Native. I would compare the knife size similar to a DF2, but I think the ergos are so much better. The Lil' Native fills/fits the hand better, but is still a small knife that can be used a little harder. I also like that the Lil' Native is wider and more stout in both the handle and blade.
I like G-10 and this one has great grip and feel. But, I just wanted to play around and try something new, so I sanded my G-10 scales on my Lil' Native. I really like the look and feel of it this way and even though it is smooth now. With the finger choil and scale shape, I still have a good hold on the knife. Just that with the sanded G-10 it looks old or classic and not so tactical.
Now, I don't have a Native 5 to compare with but I do have Chaparral LW, PM2, Para3 and BMs with most of my BMs being the smaller versions (mini grip as apposed to the grip). I don't think my hands are small, but I prefer the smaller blades for comfort and concealability. Yes the Li' Native is small, but not too small
Dragonfly G-10, Blurple PM2, Para3, Jani-Song, Dragonfly2 ZDP-189, Lil' Native, Chaparral LW, Delica WC HAP40, Para3 M4, UKPK red G10, Para3 LW, Para3 LW M390