I voted Southard, although I have no experience with the Domino. I like the Southard because of its unique design and custom feel, as mentioned by others earlier. IMO the Domino could have been called the Manix Deluxe, which def isn't a knock on the Domino, but if you're looking for something different then the Southard is much more unique. Also it has a phenomenal amount of edge for its size in the pocket; it hides more blade in its handle than seems physically possible. I snapped some shots of this way back when: http://www.spyderco.com/forums/showthre ... thard+pics
As you can see it has almost MORE edge than the Manix XL, and follows pretty much the same line. I also can't get over how the Southard looks like a clone of the Osbourne axis lock when closed, but then seems to dwarf it when open. Really impressed with this design. No it's not the slicer that many of us have become accustomed to with all the FFG offerings, but I'm OK with that. That spine hump does look a little strange, but it's a good spot for your thumb when choking up on the blade if you need to whittle a spear or something, which is definitely one of my EDC tasks.
[Edit] I'd also like to add that my only criticism of the Southard is the non-committal "jimping" it has, if those bumps can be called jimping. They're mostly a warning track to let you know that your thumb is in fact sliding forward. It could be coarser and deeper like the XM-18, or finer and more gear-like like the para, but I would have done it differently in some way. Doesn't ruin the design for me, but just a note depending on how much of a jimping snob you are.