Bring back the Jess Horn; my all-time favorite Spyderco.
More "Work," knives. I love the high end stuff, but the best thing about Spydies are their utility. How about a 3 1/2 inch wharncliffe lockback?
A dual-blade knive, but unlike the dyad have only one blade with the hole. The other would be low profile with a regular nail nick.
Wire pocket clips! I'm tired of scratches on my truck, my computer chair, etc.