Would love Spyderco to drill & tap all 3 screw clip models for LH/RH use. Four way would be even better (LH/RH TD/TU). Then supply (or at least make available from factory) sets of headless set screws, to fill in the excess holes. Black nylon and ss versions of these screws are available for other products, so this should not be difficult.
While I like the idea of a larger Native, and most definitely will buy one if they come to pass, what I'd prefer at this point is a full size Calypso, either a reissue of the PE micarta version or Jeff's suggested FRN version. Just got a PE LH CF Police and, as impressed as I am with that knife (its AWESOME) it makes me want one that size with a full flat grind. Come to think of it, a CF Police with that grind and no swedge grind would work for me too.
On that note, would also love to see, and most assuredly would buy either the Salt I, or the D'Allara Rescue with a full flat ground PE blade as well, as blunt nosed blades have a certain appeal to me. Truth be known, if Sal made both, I'd buy one of each.
I'd also like to see more models given the type of "high end" treatment Sal has gone with on the new Navigator II. Sal's almost offhand announcement of that little jewel has me more excited than anything since I first saw a picture of the Schempp Persian. Seeing as how I already own a C27 Horn, 25th Anniv Delica, Persian, and jigged bone and Santa Fe Kiwis, I think it's safe to say that I'd buy at least one of any high end PE front-lock that hit the shelves.