I use my knives for all kinds of things. For example: I used my manix lw to slice some pepperoni yesterday. Earlier in the week I used my native to prune my small lemon tree that I have indoors for the winter. Today I used my PM2 to open and break down a box. Over the weekend I used my Manix G10 to open a giant bag of cat litter. Last week I used my shaman to peel and slice plantains.
Preference really can vary and my tastes have changed over time. I own quite a few knives from several companies but they do not all regularly make it into my EDC rotation. I suppose that the most consistent traits that I prefer on my EDC knives are a secure grip in hand(which Spyderco does better than anyone), easy to clean, ease of sharpening (helps), ease of carry(size and weight in pocket) and a strong lock.
With that criteria in mind I think that my top two most carried EDCs are the Native 5 Salt and the PM2. I would place the Pacific Salt and Manix 2 right behind them .
Native 5- Small enough to carry anywhere, strong, super easy to clean and is mostly carefree. Sharpens in 5 minutes at most. I also love the grip on the N5. I can slice a tomato with the N5 (LW or G10) in blindfolded in a swimming pool of mineral oil and not cut myself. It works well for my hands and it might be my favorite EDC.
PM2- It wins on averages. It is not the best at anything but it is better at everything as an average (for my preferences). It is always enough to get the job done and I think that is partly why it is such an iconic model. It also has the best execution of the compression lock that I have handled. The open back construction makes it easy to clean and the size fits right in the middle of the N5 and Pac Salt.
Pacific Salt- Great knife for hiking , camping and gardening. Lightweight, durable, The only reason it is not my top EDC is because it is a bit large for some occasions such as going into an office meeting or opening a package in a crowded public place. It is not exactly a low key knife but it is one of the safest that I own. If I was not concerned about perception of blade length I would rate it the perfect EDC.
Manix 2- Tank of a knife. I use it for housework and tough jobs. The lightweight model is a go-to for me in the summer. The manix 2 (G10 or LW) has the most secure grip and lockup of any Spyderco I have handled.
Lately I prefer back locks over everything else because they are less likely to involuntarily open, are durable and do not have many hot spots when gripping the knife.
If spyderco ever made something like a Stretch Salt (or similar size) I think that it would likely take the top spot for me. Linerless backlock, easy to clean and maintain, easy to sharpen, choil for choking up...
With that said- At the moment when I am writing this, I am carrying my N5 Salt in my right pocket.
Just one more knife...